RR-11a analog

RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor[1][2].

Product Specifications

CAS Number

[685543-66-2]

UNSPSC

12352005

Target

Legumain; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/RR-11a_analog.html

Purity

99.12

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N[C@@H](C)C(N[C@@H](C)C(NN(CC(N)=O)C(/C=C/C(OCC)=O)=O)=O)=O)OCC1=CC=CC=C1

Molecular Formula

C22H29N5O8

Molecular Weight

491.49

References & Citations

[1]Götz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51 (9) :2816-32.|[2]Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47 (8) :1889-92.