PS432
Product Specifications
Product Name Alternative
2-(Phosphonomethyl)pentanedioic acid
UNSPSC Description
PS432 is a PKC inhibitor with IC50s of 16.9 μM (PKCι) and 18.5 μM (PKCζ), respectively. PS432 effectively inhibits the proliferation of non-small cell lung cancer cells (NSCLCs) and tumor growth in mouse xenograft models[1].
Target Antigen
PKC
Type
Reference compound
Related Pathways
Epigenetics;TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ps432.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)C(N(C2=NC3=CC=C(C)C=C3S2)C1C4=CC=C(C5=CC=C(Cl)C=C5)O4)=O)OCC
Molecular Weight
494.95
References & Citations
[1]Arencibia JM, et al. An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. ACS Chem Biol. 2017 Feb 17;12(2):564-573.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117366/PS432-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117366/PS432-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2083630-26-4
Available Sizes
Curated Selection
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