PS432

PS432 is a PKC inhibitor with IC50s of 16.9 μM (PKCι) and 18.5 μM (PKCζ), respectively. PS432 effectively inhibits the proliferation of non-small cell lung cancer cells (NSCLCs) and tumor growth in mouse xenograft models[1].

Product Specifications

CAS Number

[2083630-26-4]

Product Name Alternative

2-(Phosphonomethyl)pentanedioic acid

UNSPSC

12352005

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ps432.html

Purity

99.9

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(O)C(N(C2=NC3=CC=C(C)C=C3S2)C1C4=CC=C(C5=CC=C(Cl)C=C5)O4)=O)OCC

Molecular Formula

C25H19ClN2O5S

Molecular Weight

494.95

References & Citations

[1]Arencibia JM, et al. An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. ACS Chem Biol. 2017 Feb 17;12 (2) :564-573.