Enerisant (hydrochloride)

Enerisant (TS-091) hydrochloride is a potent, highly selective, competitive and orally active histamine H3 receptor antagonist/inverse agonist with IC50s of 2.89 nM and 14.5 nM against human and rat histamine H3 receptors, respectively[1].

Product Specifications

CAS Number

[1152749-07-9]

Product Name Alternative

TS-091 (hydrochloride)

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/enerisant-hydrochloride.html

Purity

98.72

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1CCOCC1)C2=CN(C3=CC=C(C=C3)OCCCN4[C@@H](CCC4)C)N=C2.Cl

Molecular Formula

C22H31ClN4O3

Molecular Weight

434.96

References & Citations

[1]Hino N, et al. A novel potent and selective histamine H3 receptor antagonist enerisant: in vitro profiles, in vivo receptor occupancy, and wake-promoting and procognitive effects in rodents. Journal of Pharmacology and Experimental Therapeutics, 2020, 375 (2) : 276-285.