DS89002333
DS89002333 is an orally active and potent PRKACA inhibitor, with an IC50 of 0.3 nM. DS89002333 shows good anti-tumor activity in an FL-HCC patient-derived xenograft model (expressing the DNAJB1-PRKACA fusion gene) . DS89002333 can be used in study of fibrolamellar hepatocellular carcinoma (FL-HCC) [1].
Product Specifications
CAS Number
2832159-79-0
UNSPSC
12352005
Target
PKA
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds89002333.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H]([C@]1([H])C[C@@H](O)CN1)C2=CC(Cl)=C(F)C=C2)C3=CC4=CC=NC(F)=C4C=C3OC
Molecular Formula
C22H20ClF2N3O3
Molecular Weight
447.86
References & Citations
[1]Toyota A, et al. ovel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model. Biochem Biophys Res Commun. 2022 Sep 17;621:157-161.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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