Deschloroclozapine
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging[1][2][3].
Product Specifications
CAS Number
[1977-07-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Dopamine_serotonin_antagonist-1.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1
Molecular Formula
C18H20N4
Molecular Weight
292.39
Precautions
H302, H315, H319, H335
References & Citations
18
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR3; mAChR4
Citation 01
ACS Pharmacol Transl Sci. 2025 Jun 6;8 (7) :2048-2060.|Acta Neuropathol Commun. 2024 Nov 22;12 (1) :179.|Behav Brain Funct. 2025 Nov 4;21 (1) :36.|Behav Brain Res. 2023 Oct 18:455:114674.|bioRxiv. 2020 May 18. |bioRxiv. 2023 Apr 24.|bioRxiv. 2023 Dec 22.|bioRxiv. 2023 Jun 7:2023.06.06.543911.|bioRxiv. 2023 Mar 6.|bioRxiv. 2023 May 23.|bioRxiv. 2023 Nov 17.|bioRxiv. 2023 Nov 17:2023.11.17.567492.|bioRxiv. 2023 Sep 15:2023.06.21.545778.|bioRxiv. 2024 Feb 12:2024.02.12.579861.|bioRxiv. 2024 July 02.|bioRxiv. 2024 Jun 27:2024.06.22.600167.|bioRxiv. 2024 Jun 28:2024.06.28.601172.|bioRxiv. 2024 Mar 12:2024.03.09.584200.|bioRxiv. 2024 November 03.|bioRxiv. 2025 Aug 06.|bioRxiv. 2025 Aug 07.|bioRxiv. 2025 Jun 27:2025.06.26.661815.|bioRxiv. 2025 Jun 8:2025.03.13.643119.|bioRxiv. 2025 Oct 17.|bioRxiv. July 19, 2021.|bioRxiv. November 25, 2021.|Cell Biol Toxicol. 2025 May 13;41 (1) :83.|Cell Rep Methods. 2024 Oct 21;4 (10) :100881.|Cell. 2023 Nov 22;186 (24) :5394-5410.e18.|Cell. 2025 Oct 24:S0092-8674 (25) 01129-8.|Curr Biol. 2025 Oct 29:S0960-9822 (25) 01311-9.|eNeuro. 2023 Oct 24;10 (10) :ENEURO.0162-23.2023.|eNeuro. 2025 Feb 7:ENEURO.0359-24.2025.|Eur J Neurosci. 2023 Oct;58 (8) :3737-3750.|Front Aging Neurosci. 2023 Mar 23:15:1142055.|iScience. 2021 Aug 30;24 (9) :103066.|IUBMB Life. 2024 Dec;76 (12) :1209-1222.|J Cereb Blood Flow Metab. 2021 Oct;41 (10) :2571-2582.|J Dig Dis. 2025 Jan-Feb;26 (1-2) :62-73.|Nat Commun. 2022 Apr 25;13 (1) :2233.|Nat Commun. 2022 Nov 4;13 (1) :6662.|Nat Commun. 2023 Feb 24;14 (1) :1066.|Nat Commun. 2023 Feb 28;14 (1) :971.|Nat Commun. 2023 Jul 24;14 (1) :4456.|Nat Commun. 2023 Oct 24;14 (1) :6758.|Nat Neurosci. 2020 Sep;23 (9) :1157-1167.|Nat Neurosci. 2025 Feb;28 (2) :320-335.|Nature. 2025 Aug;644 (8076) :463-472.|Nature. 2025 Jun;642 (8067) :411-420.|Neuromethods. 2023 Feb 7.|Neuron. 2021 Oct 20;109 (20) :3312-3322.e5.|Neuron. 2022 Apr 20;110 (8) :1400-1415.e6.|Neuron. 2024 Dec 4;112 (23) :3924-3939.e5.|Neuropharmacology. 2023 Sep 1:235:109576.|Neuropsychopharmacology. 2020 Oct;45 (11) :1793-1798.|Neuropsychopharmacology. 2024 Dec;49 (13) :2022-2031.|Patent. US20210275696A1.|Res Sq. 2023 Mar 27:rs.3.rs-2729263.|Research (Wash D C) . 2025 May 14:8:0701.|Research Square Preprint. 2023 Jul 24.|Sci Adv. 2024 Jul 19;10 (29) :eadp5239.|SSRN. 2025 Jun 20.|University of British Columbia. 2025.|University of Iowa. 2025.|University of Utah. 2025.|Adv Sci (Weinh) . 2025 Apr;12 (13) :e2406192.|bioRxiv. 2025 April 21.|bioRxiv. 2025 May 02.|bioRxiv. 2025 Oct 9.|bioRxiv. 2025 Sep 6.|The University of Chicago. 2023 Dec.
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