HIF-1α-IN-5
Product Specifications
UNSPSC Description
HIF-1α-IN-5 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-5 also inhibits MAO-A activity. HIF-1α-IN-5 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-5 can be used in the research of cancer[1].
Target Antigen
HIF/HIF Prolyl-Hydroxylase; Monoamine Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-1α-in-5.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=NOC2=CC=CC=C12)NC3=CC=C(N(C)C)C=C3
Molecular Weight
281.31
References & Citations
[1]Zian Xue, et al. Benzo[d]isoxazole Derivatives as Hypoxia-Inducible Factor (HIF)-1α Inhibitors. ACS Med. Chem. Lett. 2022.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151466/HIF-1α-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151466/HIF-1α-IN-5-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2826221-10-5
Available Sizes
Curated Selection
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