HIF-1α-IN-5
HIF-1α-IN-5 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell) . HIF-1α-IN-5 also inhibits MAO-A activity. HIF-1α-IN-5 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-5 can be used in the research of cancer[1].
Product Specifications
CAS Number
[2826221-10-5]
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; Monoamine Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-1α-in-5.html
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=NOC2=CC=CC=C12)NC3=CC=C(N(C)C)C=C3
Molecular Formula
C16H15N3O2
Molecular Weight
281.31
References & Citations
[1]Zian Xue, et al. Benzo[d]isoxazole Derivatives as Hypoxia-Inducible Factor (HIF) -1α Inhibitors. ACS Med. Chem. Lett. 2022.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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