Eicosanedioic acid
Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis
Product Specifications
CAS Number
[2424-92-2]
UNSPSC
12352203
Hazard Statement
H315, H319
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eicosanedioic-acid.html
Purity
99.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)CCCCCCCCCCCCCCCCCCC(O)=O
Molecular Formula
C20H38O4
Molecular Weight
342.51
Precautions
H315, H319
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
Curated Selection
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