R112

R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC50 value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis[1].

Product Specifications

CAS Number

[575474-82-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Syk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/R112.html

Purity

99.71

Solubility

DMSO : 55 mg/mL (ultrasonic)

Smiles

FC1=CN=C(NC2=CC(O)=CC=C2)N=C1NC3=CC(O)=CC=C3

Molecular Formula

C16H13FN4O2

Molecular Weight

312.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Rossi AB, et al. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J Allergy Clin Immunol. 2006 Sep;118 (3) :749-755.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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