RK-9123016
RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50 value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression[1].
Product Specifications
CAS Number
[955900-27-3]
UNSPSC
12352005
Target
C-Myc; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rk-9123016.html
Purity
99.65
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=[N+]([O-])C1=CN(N=C1)CC2=CC(/C=N/NC(NCC=C)=S)=CC=C2OC
Molecular Formula
C16H18N6O3S
Molecular Weight
374.42
References & Citations
[1]Asad Ali Shah, et al. Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity. Biol Pharm Bull. 2016;39 (10) :1739-1742.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT2
Available Sizes
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