RITA
RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.
Product Specifications
CAS Number
213261-59-7
Product Name Alternative
NSC 652287
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; DNA Alkylator/Crosslinker; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rita.html
Purity
99.79
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OCC1=CC=C(C2=CC=C(C3=CC=C(CO)S3)O2)S1
Molecular Formula
C14H12O3S2
Molecular Weight
292.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Issaeva N, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004 Dec;10 (12) :1321-8. Epub 2004 Nov 21.|[2]Nieves-Neira W, et al. DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol. 1999 Sep;56 (3) :478-84.|[3]Zhao CY, et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010 Apr 15;70 (8) :3372-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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