What is the catalog number for RITA?

The catalog number for RITA is HY-13424.

What sizes are available for RITA?

RITA is available in the following size(s): 1 mg, 5 mg, 10 mM - 1 mL, 10 mg, 50 mg, 100 mg.

How many pack sizes does RITA come in?

RITA is available in 6 different pack sizes.

RITA is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures RITA?

RITA is manufactured by QuantiMol.

What is the estimated delivery time for RITA?

Estimated delivery time for RITA is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for RITA?

The safety data sheet for RITA is available here: http://file.medchemexpress.com/batch_PDF/HY-13424/RITA-SDS-MedChemExpress.pdf.

RITA

RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.

Product Specifications

CAS Number

213261-59-7

Product Name Alternative

NSC 652287

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; DNA Alkylator/Crosslinker; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rita.html

Purity

99.79

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OCC1=CC=C(C2=CC=C(C3=CC=C(CO)S3)O2)S1

Molecular Formula

C14H12O3S2

Molecular Weight

292.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Issaeva N, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004 Dec;10 (12) :1321-8. Epub 2004 Nov 21.|[2]Nieves-Neira W, et al. DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol. 1999 Sep;56 (3) :478-84.|[3]Zhao CY, et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010 Apr 15;70 (8) :3372-81.