RITA

RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.

Product Specifications

CAS Number

[213261-59-7]

Product Name Alternative

NSC 652287

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; DNA Alkylator/Crosslinker; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rita.html

Purity

99.79

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OCC1=CC=C(C2=CC=C(C3=CC=C(CO)S3)O2)S1

Molecular Formula

C14H12O3S2

Molecular Weight

292.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Issaeva N, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004 Dec;10 (12) :1321-8. Epub 2004 Nov 21.|[2]Nieves-Neira W, et al. DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol. 1999 Sep;56 (3) :478-84.|[3]Zhao CY, et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010 Apr 15;70 (8) :3372-81.