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HGFR, Cynomolgus/Rhesus Macaque (HEK293, His)

HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque, cynomolgus-derived HGFR protein, expressed by HEK293 , with C-His labeled tag.

Product Specifications

Product Name Alternative

HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293, His), Rhesus Macaque; Cynomolgus, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/hgfr-protein-cynomolgus-rhesus-macaque-hek293-his.html

Smiles

MKAPAVLVPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETAIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPNQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPHHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYIHAFESNNFIYFLTVQRETLNAQTFHTRIIRFCSLNSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRAEFTTALQRVDLFMGQFSEVLLTSISTFVKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHPLNQNGYTLVVTGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECPSGTWTQQICLPAIYKVFPTSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPIITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLHSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFT

Molecular Formula

102123512/704562 (Gene_ID) XP_005550635.4 (E44-T951) =NP_001162100.2 (E25-T932) (Accession)

Molecular Weight

Approximately 128.2 kDa & 77.6 kDa & 45.7 kDa, based on SDS-PAGE under reducing conditions.

References & Citations

[1]Zhou H, et al. MET mutation causes muscular dysplasia and arthrogryposis. EMBO Mol Med. 2019 Mar;11 (3) :e9709.|[2]Gray MJ, et al. Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia. Am J Hum Genet. 2015 Dec 3;97 (6) :837-47.|[3]Shen Y, et al. InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase. Cell. 2000 Oct 27;103 (3) :501-10.

Shipping Conditions

Dry ice.

Scientific Category

Recombinant Proteins

Frequently Asked Questions

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