Alpinetin

Alpinetin is a flavonoid isolated from cardamom and possesses antitumor, antiinflammation, hepatoprotective, cardiovascular protective, lung protective, antibacterial, antiviral, neuroprotective properties. Alpinetin inhibits lipopolysaccharide (LPS) -induced inflammation, activates PPAR-γ, activates Nrf2, and inhibits TLR4 expression to protect LPS-induced renal injury[1][2][3][4].

Product Specifications

CAS Number

[36052-37-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Keap1-Nrf2; PPAR; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/alpinetin.html

Purity

99.51

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C[C@@H](C2=CC=CC=C2)OC3=CC(O)=CC(OC)=C13

Molecular Formula

C16H14O4

Molecular Weight

270.28

Precautions

H315, H319, H335

References & Citations

[1]Hu K, et al. Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-γ in THP-1-derived macrophages. Eur J Pharmacol. 2013 Dec 5;721 (1-3) :96-102.|[2]Zhao G, et al. Alpinetin: A Review of Its Pharmacology and Pharmacokinetics. Front Pharmacol. 2022 Feb 4;13:814370.|[3]Gul S, et al. Alpinetin: a Dietary Flavonoid with Diverse Anticancer Effects. Appl Biochem Biotechnol. 2022 Sep;194 (9) :4220-4243.|[4]Liang Y, et al. Alpinetin ameliorates inflammatory response in LPS-induced endometritis in mice. Int Immunopharmacol. 2018 Sep;62:309-312.