Alpinetin
Product Specifications
UNSPSC Description
Alpinetin is a flavonoid isolated from cardamom and possesses antitumor, antiinflammation, hepatoprotective, cardiovascular protective, lung protective, antibacterial, antiviral, neuroprotective properties. Alpinetin inhibits lipopolysaccharide (LPS)-induced inflammation, activates PPAR-γ, activates Nrf2, and inhibits TLR4 expression to protect LPS-induced renal injury[1][2][3][4].
Target Antigen
Keap1-Nrf2; PPAR; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/alpinetin.html
Purity
99.51
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C[C@@H](C2=CC=CC=C2)OC3=CC(O)=CC(OC)=C13
Molecular Weight
270.28
References & Citations
[1]Hu K, et al. Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-γ in THP-1-derived macrophages. Eur J Pharmacol. 2013 Dec 5;721(1-3):96-102.|[2]Zhao G, et al. Alpinetin: A Review of Its Pharmacology and Pharmacokinetics. Front Pharmacol. 2022 Feb 4;13:814370.|[3]Gul S, et al. Alpinetin: a Dietary Flavonoid with Diverse Anticancer Effects. Appl Biochem Biotechnol. 2022 Sep;194(9):4220-4243.|[4]Liang Y, et al. Alpinetin ameliorates inflammatory response in LPS-induced endometritis in mice. Int Immunopharmacol. 2018 Sep;62:309-312.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0625A/Alpinetin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0625A/Alpinetin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
36052-37-6
Available Sizes
Curated Selection
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