N-Arachidonyl maleimide
Product Specifications
UNSPSC Description
N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM[1].
Target Antigen
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/n-arachidonyl-maleimide.html
Smiles
O=C(C=C1)N(CCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)C1=O
Molecular Weight
369.54
References & Citations
[1]Susanna M Saario, et al. Characterization of the Sulfhydryl-Sensitive Site in the Enzyme Responsible for Hydrolysis of 2-arachidonoyl-glycerol in Rat Cerebellar Membranes. Chem Biol. 2005 Jun;12(6):649-56.|[2]James J Burston, et al. N-arachidonyl Maleimide Potentiates the Pharmacological and Biochemical Effects of the Endocannabinoid 2-arachidonylglycerol Through Inhibition of Monoacylglycerol Lipase. J Pharmacol Exp Ther. 2008 Nov;327(2):546-53.
Shipping Conditions
Dry Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-136562/N-Arachidonyl-maleimide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-136562/N-Arachidonyl-maleimide-SDS-MedChemExpress.pdf
CAS Number
876305-42-9
Available Sizes
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