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N-Arachidonyl maleimide

N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM[1].

Product Specifications

CAS Number

876305-42-9

UNSPSC

12352005

Hazard Statement

H317

Target

MAGL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/n-arachidonyl-maleimide.html

Concentration

10mM

Purity

98.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C=C1)N(CCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)C1=O

Molecular Formula

C24H35NO2

Molecular Weight

369.54

Precautions

H317

References & Citations

[1]Susanna M Saario, et al. Characterization of the Sulfhydryl-Sensitive Site in the Enzyme Responsible for Hydrolysis of 2-arachidonoyl-glycerol in Rat Cerebellar Membranes. Chem Biol. 2005 Jun;12 (6) :649-56.|[2]James J Burston, et al. N-arachidonyl Maleimide Potentiates the Pharmacological and Biochemical Effects of the Endocannabinoid 2-arachidonylglycerol Through Inhibition of Monoacylglycerol Lipase. J Pharmacol Exp Ther. 2008 Nov;327 (2) :546-53.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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