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Protein kinase inhibitor H-7 (dihydrochloride)

Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) [1].

Product Specifications

CAS Number

108930-17-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protein-kinase-inhibitor-h-7-dihydrochloride.html

Purity

99.63

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=S(C1=CC=CC2=C1C=CN=C2)(N3C(C)CNCC3)=O.[H]Cl.[H]Cl

Molecular Formula

C14H19Cl2N3O2S

Molecular Weight

364.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Fischer SM, et al. Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C. Toxicol In Vitro. 1989;3 (3) :195-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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