Protein kinase inhibitor H-7 (dihydrochloride)
Product Specifications
UNSPSC Description
Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase)[1].
Target Antigen
PKC
Type
Reference compound
Related Pathways
Epigenetics;TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protein-kinase-inhibitor-h-7-dihydrochloride.html
Purity
99.94
Solubility
DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=S(C1=CC=CC2=C1C=CN=C2)(N3C(C)CNCC3)=O.[H]Cl.[H]Cl
Molecular Weight
364.29
References & Citations
[1]Fischer SM, et al. Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C. Toxicol In Vitro. 1989;3(3):195-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100983/Protein-kinase-inhibitor-H-7-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100983/Protein-kinase-inhibitor-H-7-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
108930-17-2
Available Sizes
Curated Selection
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