LP-922056

LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats[1][2].

Product Specifications

CAS Number

[1365060-22-5]

UNSPSC

12352005

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/lp-922056.html

Concentration

10mM

Purity

99.63

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)CSC1=C2C(C(C3CC3)=C(Cl)S2)=NC=N1

Molecular Formula

C11H9ClN2O2S2

Molecular Weight

300.78

References & Citations

[1]James E Tarver Jr, et al. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett. 2016 Mar 15;26 (6) :1525-1528.|[2]Robert Brommage, et al. NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 2019 Jan 8;7:2.