FAK-IN-22
Product Specifications
UNSPSC Description
FAK-IN-22 (Compound 26) is an inhibitor of FAK, JAK3, and Aurora B, with IC50 values of 50.94 nM, 9.99 nM, and 0.49 nM, respectively, effectively inhibiting tumor occurrence and metastasis in pancreatic ductal adenocarcinoma (PDAC). FAK-IN-22 effectively inhibits the proliferation of PANC-1 cells, with an IC50 value of 0.15 μM. FAK-IN-22 induces apoptosis and G2/M phase arrest in PANC-1 cells by inhibiting the FAK/PI3K/Akt signaling pathway[1].
Target Antigen
Akt; Apoptosis; Aurora Kinase; FAK; JAK; PI3K
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics;JAK/STAT Signaling;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fak-in-22.html
Smiles
O=C(C1=CC=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC4=C3C=CN4)=N2)C=C1)NC
Molecular Weight
427.38
References & Citations
[1]Rong-Hong Zhang, et al. Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases. Eur J Med Chem. 2025 Jan 15:282:117059.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168718/FAK-IN-22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168718/
Clinical Information
No Development Reported
CAS Number
2703920-02-7
Curated Selection
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