FAK-IN-22
FAK-IN-22 (Compound 26) is an inhibitor of FAK, JAK3, and Aurora B, with IC50 values of 50.94 nM, 9.99 nM, and 0.49 nM, respectively, effectively inhibiting tumor occurrence and metastasis in pancreatic ductal adenocarcinoma (PDAC) . FAK-IN-22 effectively inhibits the proliferation of PANC-1 cells, with an IC50 value of 0.15 μM. FAK-IN-22 induces apoptosis and G2/M phase arrest in PANC-1 cells by inhibiting the FAK/PI3K/Akt signaling pathway[1].
Product Specifications
CAS Number
[2703920-02-7]
UNSPSC
12352211
Target
Akt; Apoptosis; Aurora Kinase; FAK; JAK; PI3K
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fak-in-22.html
Smiles
O=C(C1=CC=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC4=C3C=CN4)=N2)C=C1)NC
Molecular Formula
C21H16F3N5O2
Molecular Weight
427.38
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora B; JAK3
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