LYP-IN-4
LYP-IN-4 (compound D14) is a reversible and selective inhibitor of lymphotyrosine phosphatase (LYP) (Ki=1.34 μM, IC50=3.52μM) . LYP-IN-4 inhibits LYP to regulate TCR signaling, up-regulates PD-1/PD-L1 expression, and enhance anti-tumor immunity. LYP-IN-4 activates T cells and inhibits M2 macrophage polarization, inhibits tumor growth in MC38 isogenic mouse models.
Product Specifications
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lyp-in-4.html
Purity
98.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC2=CC(N(S(=O)(C(C=C3)=CC(Cl)=C3[N+]([O-])=O)=O)CC4=CC=C(C=C4)C5=CC=C(C=C5)OC)=CC=C2O1
Molecular Formula
C29H21ClN2O8S
Molecular Weight
593.00
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Sigma1 receptor (SIGMAR1) (NM_005866) Human Over-expression Lysate
N-(2-Chloroprop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine
![Calreticulin 3 (CALR3) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1D2]](https://cdn.genprice.uk/products/937/6868c368994c49e6dc3f695d/imageurl/ta505837bm.webp)