N-Boc-PEG2-bromide
N-Boc-PEG2-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG2-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[165963-71-3]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-boc-peg2-bromide.html
Purity
98.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(OC(NCCOCCOCCBr)=O)C
Molecular Formula
C11H22BrNO4
Molecular Weight
312.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Alex Cortez, et al. Antibody conjugates comprising toll-like receptor agonist and combination therapies. WO2018198091A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Cleavable Linker; PEG Linkers
Available Sizes
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