MAC-545496

MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR) . MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) . MAC-545496 is an antivirulence agent that reverses β-lactam resistance in Methicillin-resistant strains (MRSA) [1].

Product Specifications

CAS Number

[838810-96-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mac-545496.html

Purity

98.01

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC(NC1=NC=C(Cl)C=C1)=S)C2=CC=C(N3CCCCC3)C([N+]([O-])=O)=C2

Molecular Formula

C18H18ClN5O3S

Molecular Weight

419.89

Precautions

H302, H315, H319, H335

References & Citations

[1]El-Halfawy OM, et al. Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA. Nat Chem Biol. 2019 Nov 25.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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