MAC-545496
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR) . MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) . MAC-545496 is an antivirulence agent that reverses β-lactam resistance in Methicillin-resistant strains (MRSA) [1].
Product Specifications
CAS Number
[838810-96-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mac-545496.html
Purity
98.01
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC(NC1=NC=C(Cl)C=C1)=S)C2=CC=C(N3CCCCC3)C([N+]([O-])=O)=C2
Molecular Formula
C18H18ClN5O3S
Molecular Weight
419.89
Precautions
H302, H315, H319, H335
References & Citations
[1]El-Halfawy OM, et al. Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA. Nat Chem Biol. 2019 Nov 25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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