3-Dehydrotrametenolic acid

3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity[1][2].

Product Specifications

CAS Number

[29220-16-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Lactate Dehydrogenase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3-dehydrotrametenolic-acid.html

Purity

99.86

Solubility

DMSO : 14.29 mg/mL (ultrasonic)

Smiles

CC1(C)[C@@H](O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C(O)=O)CC/C=C(C)\C)CC[C@](C)4C3=CC[C@@]12[H]

Molecular Formula

C30H46O3

Molecular Weight

454.68

Precautions

H302, H315, H319, H335

References & Citations

[1]De Nicola GR, et al. Novel gram-scale production of enantiopure R-sulforaphane from Tuscan black kale seeds. Molecules. 2014 May 27;19 (6) :6975-86.|[2]Abdull Razis AF, et al. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer. 2011 Jun 15;128 (12) :2775-82.