(1α,1'S,4β) -Lanabecestat

(1α,1'S,4β) -Lanabecestat ((1α,1'S,4β) -AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM[1].

Product Specifications

CAS Number

[1384082-96-5]

Product Name Alternative

(1α,1'S,4β) -AZD3293; (1α,1'S,4β) -LY3314814

UNSPSC

12352005

Target

Beta-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-alpha-1-s-4-beta-lanabecestat.html

Purity

96.01

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

NC(C(C)=N1)=N[C@]21C3=C(C=CC(C4=CC(C#CC)=CN=C4)=C3)C[C@]52CC[C@@H](OC)CC5

Molecular Formula

C26H28N4O

Molecular Weight

412.53

References & Citations

[1]Eketjäll S, et al. AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics. J Alzheimers Dis. 2016;50 (4) :1109-23.