Melitracen (hydrochloride)

Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space[1][2].

Product Specifications

CAS Number

[10563-70-9]

UNSPSC

12352005

Hazard Statement

H301

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/melitracen-hydrochloride.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CN(C)CC/C=C1C2=C(C=CC=C2)C(C)(C)C3=CC=CC=C/13.Cl

Molecular Formula

C21H26ClN

Molecular Weight

327.89

Precautions

H301

References & Citations

[1]Xiaoqian Zhou , et al. The Efficacy of Flupentixol-Melitracen in the Adjuvant Therapy of Ulcerative Colitis in the Chinese Population: A Meta-Analysis. Gastroenterol Res Pract. 2019 Feb 28;2019:3480732.|[2]K Shimamoto, et al. Myriatic Effect of 9- (gamma-dimethylamino-propylidene) -10, 10-diemthyl-9, 10-dihydroanthracene Hydrochloride (Melitracen) in Mice and Rats. Acta Sch Med Univ Kioto. 1967 Jul;40 (1) :38-47.