VH032-cyclopropane-F
VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1) . PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1].
Product Specifications
CAS Number
2306193-99-5
Product Name Alternative
VHL ligand 3; E3 ligase Ligand 19
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-19.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(C=C1O)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O
Molecular Formula
C26H33FN4O5S
Molecular Weight
532.63
Precautions
H315, H319, H335
References & Citations
[1]Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15 (7) :672-680.|[2]Liu J, et al. FAK-targeting PROTAC demonstrates enhanced antitumor activity against KRAS mutant non-small cell lung cancer. Exp Cell Res. 2021 Nov 15;408 (2) :112868.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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