HA130

HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

Product Specifications

CAS Number

[1229652-21-4]

UNSPSC

12352005

Hazard Statement

H302

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/HA130.html

Purity

99.46

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1N(CC2=CC=C(F)C=C2)C(S/C1=C\C3=CC=C(OCC4=CC(B(O)O)=CC=C4)C=C3)=O

Molecular Formula

C24H19BFNO5S

Molecular Weight

463.29

Precautions

H302

References & Citations

[1]Zhang Y, et al. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15;189 (8) :3914-3924.|[2]Bai Z, et al. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by theautotaxin/lysophosphatidic acid axis. J Immunol. 2013 Mar 1;190 (5) :2036-2048.