PROTAC BCR-ABL Degrader-1

PROTAC BCR-ABL Degrader-1 (compound PROTAC 1) is a PROTAC with a 2-oxoethyl linker. PROTAC BCR-ABL Degrader-1 induces Bcr-Abl degradation in a ubiquitinproteasom-dependent manner. PROTAC BCR-ABL Degrader-1 exhibits antiproliferative activity against K562 cells, and has the potential to study cancer[1].

Product Specifications

UNSPSC

12352005

Target

Bcr-Abl; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-bcr-abl-degrader-1.html

Purity

98.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C=CC(NC(C1=CC=C(CN2CCN(CC(NC3=CC=CC4=C3C(N(C5C(NC(CC5)=O)=O)C4=O)=O)=O)CC2)C=C1)=O)=C6)=C6NC7=NC=CC(C8=CC=CN=C8)=N7

Molecular Formula

C43H40N10O6

Molecular Weight

792.84

References & Citations

[1]Li C, et al. Proteolysis Targeting Chimeras (PROTACs) Based on Imatinib Induced Degradation of BCR-ABL in K562 Cells. ChemistrySelect, 2023, 8 (15) : e202300095.