PROTAC BCR-ABL Degrader-1
Product Specifications
UNSPSC Description
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1) is a PROTAC with a 2-oxoethyl linker. PROTAC BCR-ABL Degrader-1 induces Bcr-Abl degradation in a ubiquitinproteasom-dependent manner. PROTAC BCR-ABL Degrader-1 exhibits antiproliferative activity against K562 cells, and has the potential to study cancer[1].
Target Antigen
Bcr-Abl; PROTACs
Type
Reference compound
Related Pathways
PROTAC;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-bcr-abl-degrader-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C=CC(NC(C1=CC=C(CN2CCN(CC(NC3=CC=CC4=C3C(N(C5C(NC(CC5)=O)=O)C4=O)=O)=O)CC2)C=C1)=O)=C6)=C6NC7=NC=CC(C8=CC=CN=C8)=N7
Molecular Weight
792.84
References & Citations
[1]Li C, et al. Proteolysis Targeting Chimeras (PROTACs) Based on Imatinib Induced Degradation of BCR-ABL in K562 Cells. ChemistrySelect, 2023, 8(15): e202300095.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153415/PROTAC-BCR-ABL-Degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153415/PROTAC-BCR-ABL-Degrader-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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