(Z) -Ligustilide

(Z) -Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6[1]. (Z) -Ligustilide is orally active, it inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2]. (Z) -Ligustilide is also able to reactivate ERα, has epigenetic regulation, and is used in the study of tamoxifen-resistant breast cancer[3].

Product Specifications

CAS Number

[81944-09-4]

UNSPSC

12352005

Hazard Statement

H301

Target

Bacterial; Estrogen Receptor/ERR; FATP

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/z-ligustilide.html

Purity

99.17

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1O/C(C2=C1C=CCC2)=C\CCC

Molecular Formula

C12H14O2

Molecular Weight

190.24

Precautions

H301

References & Citations

[1]Rodrigues AMS, et al. The antifungal potential of (Z) -ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Sci Rep. 2019 Jun 19;9 (1) :8729. doi: 10.1038/s41598-019-45222-y|[2]Ma H, et al. Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa. Oncotarget. 2017 Apr 25;8 (17) :29328-29345.|[3]Lee W, et al. Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo. Planta Med. 2019 Jul;85 (9-10) :719-728.