MK-6240

Product Specifications

CAS Number

[1841078-87-2]

UNSPSC Description

MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs[1].

Target Antigen

Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/MK-6240.html

Purity

99.60

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

NC1=C(C=CC2=C1C=C(N=C2)N3C=CC4=C3C=NC=C4)F

Molecular Weight

278.28

References & Citations

[1]Walji AM, et al. Discovery of 6-(Fluoro-(18)F)-3- (1H-pyrrolo [2,3-c]pyridin-1-yl) isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs). J Med Chem. 2016 May 26;59(10):4778-89.