MK-6240
Product Specifications
CAS Number
[1841078-87-2]
UNSPSC Description
MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs[1].
Target Antigen
Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/MK-6240.html
Purity
99.60
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
NC1=C(C=CC2=C1C=C(N=C2)N3C=CC4=C3C=NC=C4)F
Molecular Weight
278.28
References & Citations
[1]Walji AM, et al. Discovery of 6-(Fluoro-(18)F)-3- (1H-pyrrolo [2,3-c]pyridin-1-yl) isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs). J Med Chem. 2016 May 26;59(10):4778-89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Clinical Information
Phase 3
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