Talfirastide (acetate)

Angiotensin 1-7 (Ang- (1-7) ) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM) . Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium[1][2][3].

Product Specifications

CAS Number

[2855063-75-9]

Product Name Alternative

TXA127 (acetate) ; Angiotensin (1-7) (acetate) ; Ang- (1-7) (acetate)

UNSPSC

12352209

Target

Angiotensin Receptor; Angiotensin-converting Enzyme (ACE) ; Endogenous Metabolite

Type

Peptides

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Endocrinology; Inflammation/Immunology; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/angiotensin-1-7-acetate.html

Concentration

10mM

Purity

99.77

Solubility

H2O : 62.5 mg/mL (ultrasonic)

Smiles

O=C([C@H](CC1=CNC=N1)NC([C@@]([H])(NC([C@H](CC2=CC=C(C=C2)O)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(N)=N)=O)C(C)C)=O)=O)[C@H](CC)C)=O)N3CCC[C@H]3C(O)=O.CC(O)=O

Molecular Formula

C43H66N12O13

Molecular Weight

959.06

References & Citations

[1]Gómez-Mendoza DP, et al. Angiotensin- (1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4. J Proteomics. 2019;208:103486.|[2]Li P, et al. Angiotensin- (1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide. Hypertension. 1997 Jan;29 (1 Pt 2) :394-400.|[3]Khajah MA, et al. Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis. PLoS One. 2016 Mar 10;11 (3) :e0150861.|[4]Alzayadneh EM, et al. Angiotensin- (1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cell Signal. 2014 Sep 19. pii: S0898-6568 (14) 00314-3.|[5]Janatpour ZC, et al. Subcutaneous Administration of Angiotensin- (1-7) Improves Recovery after Traumatic Brain Injury in Mice. J Neurotrauma. 2019;36 (22) :3115-3131.