EGFR-IN-70
EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor with IC50 values of 23.6 and 307.5 nM for EGFRLR/TM/CS and EGFRWT, respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR. EGFR-IN-70 can be used for cancer research[1].
Product Specifications
CAS Number
2926716-96-1
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-70.html
Concentration
10mM
Purity
98.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(CC)(N1C2=CC(OCCCCCCOC3=CC(N4)=C(C)C=C3N5CCOCC5)=CC=C2C(C6=NC4=NC=C6Cl)=C1)=O
Molecular Formula
C31H36ClN5O5S
Molecular Weight
626.17
References & Citations
[1]Chen H, et, al. Conformational Constrained 4- (1-Sulfonyl-3-indol) yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65 (9) :6840-6858.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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