EGFR-IN-70

EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor with IC50 values of 23.6 and 307.5 nM for EGFRLR/TM/CS and EGFRWT, respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR. EGFR-IN-70 can be used for cancer research[1].

Product Specifications

CAS Number

[2926716-96-1]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-70.html

Concentration

10mM

Purity

98.12

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(CC)(N1C2=CC(OCCCCCCOC3=CC(N4)=C(C)C=C3N5CCOCC5)=CC=C2C(C6=NC4=NC=C6Cl)=C1)=O

Molecular Formula

C31H36ClN5O5S

Molecular Weight

626.17

References & Citations

[1]Chen H, et, al. Conformational Constrained 4- (1-Sulfonyl-3-indol) yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65 (9) :6840-6858.