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Afatinib-d6

Afatinib-d6 (BIBW 2992-d6) is deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor[1].

Product Specifications

CAS Number

[1313874-96-2]

Product Name Alternative

BIBW 2992 D6

UNSPSC

12352005

Hazard Statement

H302, H319, H373

Target

Autophagy; EGFR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.0

Solubility

DMF : ≥ 30mg/mL|DMSO : ≥ 30mg/mL|Ethanol : ≥ 30mg/mL

Smiles

O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4)/C=C/CN(C([2H])([2H])[2H])C([2H])([2H])[2H]

Molecular Formula

C24H19D6ClFN5O3

Molecular Weight

491.98

Precautions

H302, H319, H373

References & Citations

[1]Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27 (34) :4702-11.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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