Afatinib-d6
Afatinib-d6 (BIBW 2992-d6) is deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor[1].
Product Specifications
CAS Number
[1313874-96-2]
Product Name Alternative
BIBW 2992 D6
UNSPSC
12352005
Hazard Statement
H302, H319, H373
Target
Autophagy; EGFR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.0
Solubility
DMF : ≥ 30mg/mL|DMSO : ≥ 30mg/mL|Ethanol : ≥ 30mg/mL
Smiles
O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4)/C=C/CN(C([2H])([2H])[2H])C([2H])([2H])[2H]
Molecular Formula
C24H19D6ClFN5O3
Molecular Weight
491.98
Precautions
H302, H319, H373
References & Citations
[1]Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27 (34) :4702-11.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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