3-Nitrocoumarin
3-Nitrocoumarin is an inhibitor for phospholipase C that blocks the generation of inositol triphosphate (IP3), thereby affecting the calcium signaling pathway[1][2].
Product Specifications
CAS Number
[28448-04-6]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Fungal; Phospholipase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/3-nitrocoumarin.html
Purity
98.52
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C([N+]([O-])=O)=CC2=CC=CC=C2O1
Molecular Formula
C9H5NO4
Molecular Weight
191.14
Precautions
H315, H319, H320
References & Citations
[1]Tisi R, et al., Phospholipase C is required for glucose-induced calcium influx in budding yeast. FEBS Lett. 2002 Jun 5;520 (1-3) :133-8.|[2]Silverman-Gavrila LB, et al., An IP3-activated Ca2+ channel regulates fungal tip growth. J Cell Sci. 2002 Dec 15;115 (Pt 24) :5013-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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