UNBS5162
UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.
Product Specifications
CAS Number
956590-23-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; CXCR
Type
Reference compound
Related Pathways
Autophagy; GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/UNBS5162.html
Purity
99.92
Solubility
DMSO : 21.5 mg/mL (ultrasonic; warming)
Smiles
O=C(N)NC1=CC2=CC=CC(C(N(CCN(C)C)C3=O)=O)=C2C3=C1
Molecular Formula
C17H18N4O3
Molecular Weight
326.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Mijatovic T, et al. UNBS5162, a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Neoplasia. 2008 Jun;10 (6) :573-86.|[2]Tina Mahieu, et al. UNBS5162: A novel naphthalimide derivative with potent pro-autophagic effects in human cancer cells. Cancer Research, 2007 May; 67 (9) Supplement.|[3]He D, et al. UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway. Mol Med Rep. 2018 Jan;17 (1) :549-555.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC470218-100 1x 100 µL
CD100 (Semaphorin-4D) (A8), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400669-500 1x 500 µL
P27 / KIP1 (SX53G8), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940178-100 1x 100 µL
CD50 (ICAM-3) (186-2G9), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400419-500 1x 500 µL
Transglutaminase II (TGM2/419), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details