UNBS5162

UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.

Product Specifications

CAS Number

[956590-23-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; CXCR

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/UNBS5162.html

Purity

99.92

Solubility

DMSO : 21.5 mg/mL (ultrasonic; warming)

Smiles

O=C(N)NC1=CC2=CC=CC(C(N(CCN(C)C)C3=O)=O)=C2C3=C1

Molecular Formula

C17H18N4O3

Molecular Weight

326.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Mijatovic T, et al. UNBS5162, a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Neoplasia. 2008 Jun;10 (6) :573-86.|[2]Tina Mahieu, et al. UNBS5162: A novel naphthalimide derivative with potent pro-autophagic effects in human cancer cells. Cancer Research, 2007 May; 67 (9) Supplement.|[3]He D, et al. UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway. Mol Med Rep. 2018 Jan;17 (1) :549-555.