MitTx-alpha
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs) . MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH100-fold) proton-evoked activation of ASIC2a channels[1].
Product Specifications
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mittx-alpha.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3C(C)C)=O)=O)=O)NC4=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC%10=CNC=N%10)C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(N[C@@H](CO)C(N[C@H]4CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%12=O)C(NCC(N[C@@H](C)C(N[C@@H](CC%13=CC=CC=C%13)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC%14=CC=C(C=C%14)O)C(N[C@@H](CC%15=CC=C(C=C%15)O)C(N[C@@H](CC%16=CC=CC=C%16)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC%17=CNC=N%17)C(NCC(O)=O)=O)=O)NC3=O)C(N[C@@H](C(C)C)C(N[C@@H](CC%18=CNC=N%18)C(N[C@@H](CC%19=CC=CC=C%19)C(N[C@@H](CC%20=CC=CC=C%20)C(N[C@@H](CC%21=CC=C(C=C%21)O)C(NCC(N[C@H]%12CCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)NC([C@@H]%22CCC(N%22)=O)=O
Molecular Formula
C317H440N87O89S7
Molecular Weight
7103.94
References & Citations
[1]Christopher J Bohlen, et al. A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature. 2011 Nov 16;479 (7373) :410-4.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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