Thalidomide-4-O-C11-NH2 (hydrochloride)
Thalidomide-4-O-C11-NH2 hydrochloride is the Thalidomide (HY-10984) -based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-4-o-c11-nh2-hydrochloride.html
Purity
99.94
Solubility
10 mM in DMSO
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C(C(OCCCCCCCCCCCN)=CC=C3)=C3C1=O.Cl
Molecular Formula
C24H34ClN3O5
Molecular Weight
480.00
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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