LY900009

LY900009 is a potent and orally active, First-in-class inhibitor of Notch signaling via selective inhibition of the γ-secretase protein (GSI) . LY900009 inhibits Notch signalling in tumor cell lines and endothelial cells (IC50=0.005-20 nM) . LY900009 can be used for advanced cancer research[1].

Product Specifications

CAS Number

[209984-68-9]

UNSPSC

12352005

Target

Notch; γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ly900009.html

Purity

98.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)[C@H](O)C(N[C@@H](C)C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C)C1=O)=O)=O

Molecular Formula

C23H27N3O4

Molecular Weight

409.48

References & Citations

[1]Shubham Pant, et al. A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer. Eur J Cancer. 2016 Mar;56:1-9.