AA92593

AA92593 is a selective and competitive melanopsin OPN4 antagonist[1][2].

Product Specifications

CAS Number

[457961-34-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/aa92593.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(N1CCCCC1)(C2=CC=C(OC)C(C)=C2)=O

Molecular Formula

C13H19NO3S

Molecular Weight

269.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Maria Nathália Moraes, et al. Melanopsin, a Canonical Light Receptor, Mediates Thermal Activation of Clock Genes. Sci Rep. 2017 Oct 25;7 (1) :13977.|[2]Victoria Eugenia Lledó, et al. Yellow Filter Effect on Melatonin Secretion in the Eye: Role in IOP Regulation. Curr Eye Res. 2019 Jun;44 (6) :614-618.|[3]Gabriel E Bertolesi, et al. Melanopsin photoreception in the eye regulates light-induced skin colour changes through the production of α-MSH in the pituitary gland. Pigment Cell Melanoma Res. 2015 Sep;28 (5) :559-71.|[4]Kenneth A Jones, et al. Small-molecule antagonists of melanopsin-mediated phototransduction. Nat Chem Biol. 2013 Oct;9 (10) :630-5.