IRES-C11
IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes[1][2].
Product Specifications
CAS Number
342416-30-2
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
C-Myc
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ires-c11.html
Purity
98.01
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C(Cl)=C1Cl)N(CC2=CC=C(OC)C=C2OC)C1=O
Molecular Formula
C13H11Cl2NO4
Molecular Weight
316.14
Precautions
H302+H312+H332
References & Citations
[1]Brent Holmes, et al. Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES) -mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma. J Biol Chem. 2016 Jul 1;291 (27) :14146-14159.|[2]Y Shi, et al. Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress. Oncogene. 2016 Feb 25;35 (8) :1015-24.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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