Norverapamil-d7 (hydrochloride)

Norverapamil-d7 (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±) -Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

Product Specifications

CAS Number

[1216413-74-9]

Product Name Alternative

(±) -Norverapamil-d7 (hydrochloride) ; D591-d7 (hydrochloride)

UNSPSC

12352005

Target

Calcium Channel; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

98.77

Solubility

H2O : 15 mg/mL (ultrasonic; warming)

Smiles

N#CC(C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])(CCCNCCC1=CC=C(OC)C(OC)=C1)C2=CC=C(OC)C(OC)=C2.[H]Cl

Molecular Formula

C26H30D7ClN2O4

Molecular Weight

484.08

References & Citations

[1]Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210 (3) :456-66.|[2]Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293 (2) :376-82.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.