Rhein
Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects[1].
Product Specifications
CAS Number
478-43-3
Product Name Alternative
Rheic Acid; Rhubarb yellow; Monorhein
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Autophagy; Bacterial; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Rhein.html
Purity
99.73
Solubility
DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(C=C1C2=O)=CC(O)=C1C(C3=C2C=CC=C3O)=O)O
Molecular Formula
C15H8O6
Molecular Weight
284.22
Precautions
H315, H319, H335
References & Citations
[1]Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355 (1) :125-34.|[2]Heo SK, et al. Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells. Phytomedicine. 2018 Oct 1;49:66-74.|[3]Zhao YL, et al. Rhein protects against acetaminophen-induced hepatic and renal toxicity. Food Chem Toxicol. 2011 Aug;49 (8) :1705-10. |[4]Fernand VE, et al. Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro. Chem Biol Interact. 2011 Jul 15;192 (3) :220-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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