Rhein

Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects[1].

Product Specifications

CAS Number

[478-43-3]

Product Name Alternative

Rheic Acid; Rhubarb yellow; Monorhein

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Autophagy; Bacterial; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Rhein.html

Purity

99.73

Solubility

DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(C=C1C2=O)=CC(O)=C1C(C3=C2C=CC=C3O)=O)O

Molecular Formula

C15H8O6

Molecular Weight

284.22

Precautions

H315, H319, H335

References & Citations

[1]Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355 (1) :125-34.|[2]Heo SK, et al. Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells. Phytomedicine. 2018 Oct 1;49:66-74.|[3]Zhao YL, et al. Rhein protects against acetaminophen-induced hepatic and renal toxicity. Food Chem Toxicol. 2011 Aug;49 (8) :1705-10. |[4]Fernand VE, et al. Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro. Chem Biol Interact. 2011 Jul 15;192 (3) :220-32.