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PPARγ-IN-2

PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. PPARγ-IN-2 inhibits TG accumulation in 3T3-L1 preadipocytes (EC50: 0.106 μM) . PPARγ-IN-2 inhibits high-cholesterol diet (HFC) -induced obesity and related metabolic syndrome, and reduces lipid accumulation in adipose tissue[1].

Product Specifications

CAS Number

2682078-97-1

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pparγ-in-2.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=CC1=C(C2=NC=CC(NCCN3CCCC3)=N2)NC4=CC=CC=C14

Molecular Formula

C19H21N5O

Molecular Weight

335.40

References & Citations

[1]Guo SY, et al. Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism. Eur J Med Chem. 2023 Nov 15;260:115729.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PPARγ

Available Sizes

Frequently Asked Questions

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