Huwentoxin XVI (TFA)
Huwentoxin XVI TFA, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC50 of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI TFA has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels[1].
Product Specifications
UNSPSC
12352209
Target
Calcium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/huwentoxin-xvi-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.O=C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CNC=N3)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@H]8CC9=CC=C(C=C9)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%10=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N%11[C@@H](CCC%11)C(N[C@@H](CCCNC(N)=N)C(N[C@H]%12CSSC[C@@H](C(N[C@@H](CC%13=CC=C(C=C%13)O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)NC8=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(N[C@H]%10C(C)C)=O)=O)=O)=O)NC%12=O)N
Molecular Formula
C198H293F3N50O58S6
Molecular Weight
4551.15
References & Citations
[1]Meichun Deng, et al. Huwentoxin-XVI, an analgesic, highly reversible mammalian N-type calcium channel antagonist from Chinese tarantula Ornithoctonus huwena. Neuropharmacology. 2014 Apr;79:657-67.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
N-type calcium channel
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940994-100 1x 100 µL
TNF alpha (J2D10), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880679-100 1x 100 µL
CD171 / L1CAM (L1 Cell Adhesion Molecule) (UJ127), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040676-500 1x 500 µL
MUC18 / Mucin 18 / CD146 (OJ79c), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
