SC-43
SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects[1][2].
Product Specifications
CAS Number
1400989-25-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Phosphatase; SHP1; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sc-43.html
Purity
99.01
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(OC2=CC=C(C#N)C=C2)=C1)NC3=CC=C(Cl)C(C(F)(F)F)=C3
Molecular Formula
C21H13ClF3N3O2
Molecular Weight
431.80
Precautions
H302, H315, H319, H335
References & Citations
[1]Ming-Hung Hu, et al. Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma. Oncotarget. 2017 May 10;8 (39) :65077-65089.|[2]Tung-Hung Su, et al. Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. Sci Rep. 2017 May 11;7 (1) :1728.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
STAT3
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb1051046 100 µL
Atrial natriuretic factor Rabbit Polyclonal Antibody (RBITC)
Sign In for Pricing
View Details 
MBS2053937-01 0.1 mL
FITC-Linked Polyclonal Antibody to Growth Associated Protein 43 (GAP43)
Sign In for Pricing
View Details MBS2053937-02 0.2 mL
FITC-Linked Polyclonal Antibody to Growth Associated Protein 43 (GAP43)
Sign In for Pricing
View Details MBS2053937-03 0.5 mL
FITC-Linked Polyclonal Antibody to Growth Associated Protein 43 (GAP43)
Sign In for Pricing
View Details